2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Opioid Receptor

Opioid Receptor

Receptor

Opioid Receptor

Related Products

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Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Isoform Specific Products:

Opioid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P0088
    Porcine dynorphin A(1-13)
    		Agonist 99.85%
    Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.
    Porcine dynorphin A(1-13)
  • HY-G0021
    N-Desmethylclozapine
    		Agonist 98.99%
    N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.
    N-Desmethylclozapine
  • HY-12363
    U-69593
    		Agonist 99.73%
    U-69593 is a potent and selective κ1-opioid receptor agonist. U-69593 attenuates addictive agent-induced behavioral sensitization in the rat. U-69593 reduces anxiety and enhances spontaneous alternation memory in mice. U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum.
    U-69593
  • HY-P1336
    Deltorphin I
    		Agonist
    Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.
    Deltorphin I
  • HY-P2159
    Dynorphin A (1-8)
    		99.88%
    Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM).
    Dynorphin A (1-8)
  • HY-P1701
    Morphiceptin
    		98.29%
    Morphiceptin is a potent and specific agonist for morphine (μ) receptors. Morphiceptin, as a synthetic peptide, is the amide of a fragment of the milk protein β-casein. Morphiceptin has morphinelike activities and is highly specific for morphine (μ) receptors but not for enkephalin (⸹) receptors.
    Morphiceptin
  • HY-15997B
    (±)-U-50488 hydrochloride
    		Agonist 99.73%
    (±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrochloride is a selective κ opioid receptor (KOR) agonist.
    (±)-U-50488 hydrochloride
  • HY-P0186A
    Endomorphin 2 TFA
    		Agonist 99.43%
    Endomorphin 2 TFA, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.
    Endomorphin 2 TFA
  • HY-137279
    Naloxone methiodide
    		Antagonist 99.7%
    Naloxone methiodide is a peripherally restricted, nonselective, and competitive opioid receptor antagonist. Naloxone methiodide does not penetrate the blood-brain barrier.
    Naloxone methiodide
  • HY-A0118A
    Naloxegol oxalate
    		Antagonist 99.91%
    Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation.
    Naloxegol oxalate
  • HY-13716
    Noscapine
    		Agonist 99.98%
    Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier.
    Noscapine
  • HY-13222
    BAN ORL 24
    		Antagonist 99.68%
    BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic.
    BAN ORL 24
  • HY-17417A
    Naloxone
    		Antagonist 99.71%
    Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias.
    Naloxone
  • HY-P0179
    β-Casomorphin, bovine
    		Agonist 99.89%
    β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.
    β-Casomorphin, bovine
  • HY-P1594A
    Dynorphin A (1-10) (TFA)
    		Agonist
    Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC50 of 42.0 μM.
    Dynorphin A (1-10) (TFA)
  • HY-P0210B
    DAMGO TFA
    		Agonist 99.60%
    DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR.
    DAMGO TFA
  • HY-13101
    MCOPPB trihydrochloride
    		Agonist 99.98%
    MCOPPB trihydrochloride is a nociceptin receptor agonist with pKi of 10.
    MCOPPB trihydrochloride
  • HY-P1329A
    CTOP TFA
    		Antagonist 99.84%
    CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity.
    CTOP TFA
  • HY-139690
    CCG258747
    		Inhibitor 98.96%
    CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, >5500, and >550–fold, respectively).CCG258747 also blocks the internalization of the µ-opioid receptor. G protein-coupled receptor (GPCR) kinases (GRKs) are attractive targets for the research of heart failure.
    CCG258747
  • HY-117040
    nor-Binaltorphimine
    		Antagonist 98.70%
    nor-Binaltorphimine is a selective antagonist of kappa-opioid receptor. nor-Binaltorphimine has a long-lasting effect in vivo.
    nor-Binaltorphimine
Cat. No. Product Name / Synonyms Application Reactivity
Opioid Receptor Isoform Comparison

μ Opioid Receptor/MOR

κ Opioid Receptor/KOR

δ Opioid Receptor/DOR

NOP Receptor/ORL1

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Opioid Receptor Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Nameμ Opioid Receptor/MORκ Opioid Receptor/KORδ Opioid Receptor/DORNOP Receptor/ORL1Purity    
DAMGO
μ Opioid Receptor/MOR
   99.90%
Matrine
μ Opioid Receptor/MOR
κ Opioid Receptor/KOR
  ≥98.0%
Isotodesnitazene
μ Opioid Receptor/MOR
   99.78%
Sinomenine
μ Opioid Receptor/MOR
   99.94%
Sinomenine hydrochloride
μ Opioid Receptor/MOR
   98.67%
Norbinaltorphimine dihydrochloride 
κ Opioid Receptor/KOR
  98.91%
Dynorphin A 
κ Opioid Receptor/KOR
  98.06%
β-Endorphin, human  
δ Opioid Receptor/DOR
 98.09%
JTC-801   
NOP Receptor/ORL1
98.91%
SNC80  
δ Opioid Receptor/DOR
 99.44%
Difelikefalin 
κ Opioid Receptor/KOR
  99.50%
BMS-986122
μ Opioid Receptor/MOR
   99.94%
Endomorphin 1
μ Opioid Receptor/MOR, Ki: 1.11 nM
   99.92%
Alvimopan dihydrate
μ Opioid Receptor/MOR
   98.66%
LY2940094   
NOP Receptor/ORL1
99.91%
Corydaline
μ Opioid Receptor/MOR
   99.70%
SB-612111 hydrochloride   
NOP Receptor/ORL1
99.26%
PZM21
μ Opioid Receptor/MOR
   99.46%
DPDPE  
δ Opioid Receptor/DOR
 99.83%
Navacaprant
μ Opioid Receptor/MOR, IC50: 110 nM
κ Opioid Receptor/KOR, IC50: 0.8 nM
δ Opioid Receptor/DOR, IC50: 6500 nM
 99.97%
CTAP TFA
μ Opioid Receptor/MOR, IC50: 3.5 nM
 
δ Opioid Receptor/DOR, IC50: 4500 nM
 99.60%
Dermorphin
μ Opioid Receptor/MOR
   99.96%
Naldemedine tosylate
μ Opioid Receptor/MOR
   
BMS-986187  
δ Opioid Receptor/DOR
 98.93%
[Met5]-Enkephalin, amide TFA  
δ Opioid Receptor/DOR
 99.58%
Porcine dynorphin A(1-13) 
κ Opioid Receptor/KOR
  99.85%
N-Desmethylclozapine  
δ Opioid Receptor/DOR
 98.99%
U-69593 
κ Opioid Receptor/KOR
  99.73%
Deltorphin I  
δ Opioid Receptor/DOR
 
Dynorphin A (1-8) 
κ Opioid Receptor/KOR
  99.88%
Morphiceptin
μ Opioid Receptor/MOR
   98.29%
Endomorphin 2 TFA
μ Opioid Receptor/MOR
   99.43%
BAN ORL 24   
NOP Receptor/ORL1
99.68%
Dynorphin A (1-10) (TFA) 
κ Opioid Receptor/KOR
  
DAMGO TFA
μ Opioid Receptor/MOR
   99.60%
CTOP TFA
μ Opioid Receptor/MOR
   99.84%
Deltorphin 2 TFA  
δ Opioid Receptor/DOR
 99.93%
Ro 64-6198   
NOP Receptor/ORL1
99.82%
TAN-452  
δ Opioid Receptor/DOR
 99.44%
SNC162  
δ Opioid Receptor/DOR
 99.72%
ADL-5859 hydrochloride  
δ Opioid Receptor/DOR
 99.77%
UFP-101 TFA   
NOP Receptor/ORL1
99.36%
CYM51010
μ Opioid Receptor/MOR
   99.12%
Sec-O-Glucosylhamaudol
μ Opioid Receptor/MOR
   99.81%
GSK1521498 free base
μ Opioid Receptor/MOR
   98.55%
Trimebutine
μ Opioid Receptor/MOR
   99.40%
Adrenorphin
μ Opioid Receptor/MOR
   
J-113397
μ Opioid Receptor/MOR, Ki: 1000 ± 160 nM
κ Opioid Receptor/KOR, Ki: 640 ± 87 nM
δ Opioid Receptor/DOR, Ki: >10000 nM
NOP Receptor/ORL1, Ki: 1.8 ± 0.24 nM
99.00%
(±)-J-113397   
NOP Receptor/ORL1
98.59%
Naloxonazine dihydrochloride
μ Opioid Receptor/MOR, IC50: 5.4 nM
   98.1%
Dynorphin B (1-13) TFA 
κ Opioid Receptor/KOR
  
KNT-127  
δ Opioid Receptor/DOR
 99.60%
ICI 199441 
κ Opioid Receptor/KOR
  99.39%
Endomorphin 1 acetate
μ Opioid Receptor/MOR, Ki: 1.11 nM
   99.92%
SR17018
μ Opioid Receptor/MOR
   98.01%
MT-7716 hydrochloride   
NOP Receptor/ORL1
99.06%
AR-M 1000390 hydrochloride  
δ Opioid Receptor/DOR
 98.20%
[D-Ala2]leucine-enkephalin  
δ Opioid Receptor/DOR
 98.64%
5'-Guanidinonaltrindole hydrochloride
human μ-opioid receptor, Ki: 36.9 nM
human μ-opioid receptor, pA2: 8.49
   98.72%
TAN-67 dihydrobromide  
δ Opioid Receptor/DOR, Ki: 0.647 nM
 99.20%
LY255582
μ Opioid Receptor/MOR, Ki: 0.4 nM
κ Opioid Receptor/KOR, Ki: 2.0 nM
δ Opioid Receptor/DOR, Ki: 5.2 nM
 ≥98.0%
Asimadoline hydrochloride 
κ Opioid Receptor/KOR
  99.82%
DIPPA hydrochloride 
κ Opioid Receptor/KOR
  99.7%
Nociceptin (1-13), amide TFA   
NOP Receptor/ORL1
99.67%
Deltorphin 2  
δ Opioid Receptor/DOR
 
BMS-986121
μ Opioid Receptor/MOR
   98.89%
Bevenopran
μ Opioid Receptor/MOR
   99.82%
DPDPE TFA  
δ Opioid Receptor/DOR
 99.94%
Gluten Exorphin C
μ Opioid Receptor/MOR
 
δ Opioid Receptor/DOR
 99.86%
β-Endorphin, equine TFA
μ Opioid Receptor/MOR
 
δ Opioid Receptor/DOR
 
Cebranopadol ((1α,4α)stereoisomer)   
NOP Receptor/ORL1
LY2444296 
κ Opioid Receptor/KOR
  99.59%
Dalargin  
δ Opioid Receptor/DOR
 99.52%
Samidorphan-d5
μ Opioid Receptor/MOR
κ Opioid Receptor/KOR
δ Opioid Receptor/DOR
 
Alvimopan monohydrate
μ Opioid Receptor/MOR
   99.18%
GSK1521498 free base (hydrochloride)
μ Opioid Receptor/MOR
   
CTAP
μ Opioid Receptor/MOR, IC50: 3.5 nM
 
δ Opioid Receptor/DOR, IC50: 4500 nM
 
AT-076
μ Opioid Receptor/MOR, IC50: 1.67 nM
κ Opioid Receptor/KOR, IC50: 1.14 nM
δ Opioid Receptor/DOR, IC50: 19.6 nM
NOP Receptor/ORL1, IC50: 1.75 nM
SC13
μ Opioid Receptor/MOR
   
SalA-VS-07 
κ Opioid Receptor/KOR
  
NAQ
μ Opioid Receptor/MOR, Ki: 0.55 nM
κ Opioid Receptor/KOR, Ki: 26.45 nM
δ Opioid Receptor/DOR, Ki: 132.50 nM
 
KOR agonist 4
human μ-opioid receptor, Ki: 280 nM
human κ-opioid receptor (hKOR), EC50: 14 nM
human κ-opioid receptor (hKOR), Ki: 4.8 nM
δ Opioid Receptor/DOR, Ki: 3900 nM
 
N-Desmethylclozapine-d8  
δ Opioid Receptor/DOR
 
Nociceptin (1-13), amide   
NOP Receptor/ORL1
Mu opioid receptor antagonist 4
μ Opioid Receptor/MOR
   
SB-612111   
NOP Receptor/ORL1
Bilaid C
human μ-opioid receptor, Ki: 210 nM
   
Dermorphin TFA
μ Opioid Receptor/MOR
   
DALDA
μ Opioid Receptor/MOR, Ki: 1.69 nM
κ Opioid Receptor/KOR, Ki: 4230 nM
δ Opioid Receptor/DOR, Ki: 19200 nM
 
KOR/DOR agonist 1
μ Opioid Receptor/MOR, Ki: 0.93 nM
κ Opioid Receptor/KOR, Ki: 0.14 nM
δ Opioid Receptor/DOR, Ki: 0.2 nM
 
Acetalin-3
μ Opioid Receptor/MOR
   
KOR agonist 3
μ Opioid Receptor/MOR, EC50: 720 nM
κ Opioid Receptor/KOR, EC50: 0.88 nM
  
DS34942424
μ Opioid Receptor/MOR
   
Bilaid A1e
μ Opioid Receptor/MOR, Ki: 750 nM
   
LY2048978
μ Opioid Receptor/MOR, Ki: 0.287 nM
κ Opioid Receptor/KOR, Ki: 0.471 nM
δ Opioid Receptor/DOR, Ki: 1.05 nM
 
Mu opioid receptor antagonist 5
μ Opioid Receptor/MOR
   
(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) 
κ Opioid Receptor/KOR
  
Mu opioid receptor antagonist 3
μ Opioid Receptor/MOR
   
AP-238
μ Opioid Receptor/MOR, EC50: 248 nM
   
KOR agonist 2 
κ Opioid Receptor/KOR, Ki: 1.9 nM
  
AT-121 hydrochloride
μ Opioid Receptor/MOR
   
MT-7716 free base   
NOP Receptor/ORL1
Nociceptin(1-7)   
NOP Receptor/ORL1
Mu opioid receptor antagonist 2
μ Opioid Receptor/MOR
   
Dynorphin A TFA 
κ Opioid Receptor/KOR
  
rel-SB-612111 hydrochloride   
NOP Receptor/ORL1
PIPE-3297 
κ Opioid Receptor/KOR, EC50: 1.1 nM
  
[DPen2, Pen5] Enkephalin  
δ Opioid Receptor/DOR
 
GSK1521498
μ Opioid Receptor/MOR
   
Trap-101 hydrochloride   
NOP Receptor/ORL1
Anrikefon 
κ Opioid Receptor/KOR
  
β-Funaltrexamine hydrochloride
μ Opioid Receptor/MOR
   
ZP 120C   
NOP Receptor/ORL1
3-Carboxamidonaltrexone
μ Opioid Receptor/MOR, Ki: 1.9 nM
κ Opioid Receptor/KOR, Ki: 22 nM
δ Opioid Receptor/DOR, Ki: 110 nM
 
KOR agonist 1
μ Opioid Receptor/MOR, EC50: 701.2 nM
κ Opioid Receptor/KOR, EC50: 3.4 nM
δ Opioid Receptor/DOR, EC50: 1649 nM
 
[Met5]-Enkephalin, amide  
δ Opioid Receptor/DOR
 
Mu opioid receptor antagonist 7
μ Opioid Receptor/MOR, IC50: 29 ± 3.0 nM
   
DPI-3290 
κ Opioid Receptor/KOR
δ Opioid Receptor/DOR
 
N-Benzylnaltrindole hydrochloride  
δ Opioid Receptor/DOR
 
Dynorphin A (1-10) 
κ Opioid Receptor/KOR
  
Akuammidine 
κ Opioid Receptor/KOR
  
Mu opioid receptor antagonist 1
μ Opioid Receptor/MOR
   
K-Opioid receptor agonist-1
μ Opioid Receptor/MOR, Ki: 43 nM
κ Opioid Receptor/KOR, Ki: 0.25 nM
δ Opioid Receptor/DOR, Ki: 58 nM
 
Ac-RYYRWK-NH2 TFA   
NOP Receptor/ORL1
μ opioid receptor agonist 3
μ Opioid Receptor/MOR, EC50: 0.82 nM
   
BAM-12P 
human κ-opioid receptor (hKOR), EC50: 101 nM
human κ-opioid receptor (hKOR), pEC50: 6.99
  
Naloxegol-d5 oxalate
μ Opioid Receptor/MOR
   
Nociceptin(1-7) TFA   
NOP Receptor/ORL1
MOR modulator-1
μ Opioid Receptor/MOR, Ki: 0.25 nM
κ Opioid Receptor/KOR, Ki: 1.3 nM
δ Opioid Receptor/DOR, Ki: 41.1 nM
 
UFP-101   
NOP Receptor/ORL1
Acetalin-1
μ Opioid Receptor/MOR
   
CTOP
μ Opioid Receptor/MOR
   
Axelopran
human μ-opioid receptor, pKi: 9.8
guinea pig κ-opioid receptor, pKi: 9.9
δ Opioid Receptor/DOR, pKi: 8.8
 
δ opioid receptor antagonist 1  
δ Opioid Receptor/DOR, Ki: 1.7 nM
 
Opioid receptor agonist 1
μ Opioid Receptor/MOR, Ki: 5 nM
κ Opioid Receptor/KOR, Ki: 212 nM
δ Opioid Receptor/DOR, Ki: 24 nM
 
MOR agonist-2
μ Opioid Receptor/MOR
   
α-Endorphin (human)
μ Opioid Receptor/MOR
   
Dermorphin Analog
μ Opioid Receptor/MOR
   
DSLET  
δ Opioid Receptor/DOR
 
NPFF1-R antagonist 1
μ Opioid Receptor/MOR, Ki: 3560 ± 364 nM
κ Opioid Receptor/KOR, Ki: 1390 ± 147 nM
δ Opioid Receptor/DOR, Ki: 1540 ± 132 nM
 
FEKAP 
κ Opioid Receptor/KOR, Ki: 0.43 nM
  
RX809055AX
μ Opioid Receptor/MOR
 
δ Opioid Receptor/DOR
 
R-84760 
κ Opioid Receptor/KOR
  
U-48520
μ Opioid Receptor/MOR, EC50: 1561 nM
   
Salvinorin A propionate 
κ Opioid Receptor/KOR
  
CHIR 4531
μ Opioid Receptor/MOR, Ki: 6 nM
   
Picraline
μ Opioid Receptor/MOR, Ki: 132 μM
κ Opioid Receptor/KOR, Ki: 2.38 μM
δ Opioid Receptor/DOR, Ki: 98.8 μM
 
BNTX  
δ Opioid Receptor/DOR
 
Salvinorin A carbamate 
κ Opioid Receptor/KOR, EC50: 6.2 nM
  
Endomorphin 2
μ Opioid Receptor/MOR